Significance of inflammation markers in patients with coronary microvascular dysfunction and non-obstructive coronary artery disease

Aim. To study the relationship of coronary microvascular dysfunction (CMD) with levels pro- and anti-inflammatory biomarkers in patients preserved ejection fraction (LVEF) non-obstructive artery disease (CAD). Material methods . The included 118 (70 men, mean age, 62,0 [58,0; 69,0] years) LVEF (62 [59; 64] %) CAD. Serum N-terminal pro-brain natriuretic peptide (NT-proBNP), high-sensitivity C-reactive protein (hsCRP), interleukin-1β, 6, 10 were assessed initially by enzyme immunoassay. Coronary flow reserve (CFR) was dynamic single photon emission computed tomography. CFR ≤2 a CMD marker. Results. Patients divided into groups depending on presence: group 1 (n=45), 2 control without (n=73). HsCRP concentrations 1,8 times higher (p=0,011) compared to 2. Interleukin-6 did not differ significantly between (p=0,842), while interleukin-10 lower 21,7 % (p=0,048), interleukin-1β 2,7 (p=0,046) According ROC analysis, hsCRP concentration ≥4,8 g/l (AUC=0,655; p=0,012), NT-proBNP ≥950,6 pg/ml (AUC=0,792; p<0,001) identified as markers associated CAD, 6 showed no diagnostic significance. Multivariate regression analysis that diastolic (odds ratio, 3,27; 95% confidence interval, 2,26-5,64; 2,07; 1,56-4,12; p=0,023) independent factors CMD. Conclusion We established pre­sence is expression pro-inflammatory decrease an marker, which may confirm fact chronic inflammation one pathogenesis links.